RetinaDigest

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Abstract not available — see full article for details.

In a 4-year prospective cohort of 577 iAMD eyes, specific structural OCT biomarkers—including SDDs, PED, nCNV, and cRORA—predicted progression to GA or nAMD, with distinct biomarker profiles differentiating the two progression pathways.

This systematic review and meta-analysis of 4,043 eyes found that greater baseline PED height (MD +212 µm) and larger PED area (MD +5.80 mm²) are the most consistently reported associations with RPE tear development in neovascular AMD, though evidence quality remains very low due to predominantly retrospective, unadjusted study designs.

This three-case series demonstrates significant clinical and longitudinal heterogeneity within the acute outer retinopathy (AOR) spectrum, encompassing asymptomatic subacute-chronic disease, perivenular disease with structure-function dissociation, and symptomatic sectoral disease with diffuse photoreceptor dysfunction.

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This review examines vitamin D's immunoregulatory role in uveitis, finding that while observational data consistently link vitamin D deficiency to increased disease activity and recurrence, interventional evidence remains insufficient to support routine supplementation.

This systematic review of 122 studies evaluated multimodal imaging (MMI) across five major infectious posterior uveitides, finding that CFP and OCT achieved high certainty evidence for diagnosis and longitudinal monitoring in 80% of entities, while combined MMI strategies provide superior structural, vascular, and choroidal assessment beyond conventional examination.

This report describes the first two confirmed HLA-A29-positive Birdshot Chorioretinopathy (BSCR) cases from Egypt, expanding the known demographic distribution of this condition beyond its traditionally reported Northern European ancestry population.

Oral belzutifan produced substantial regression of retinal capillary hemangioblastomas in VHL disease, reducing active lesion area by ~75% at 1 year and ~80% at 2 years, with no new lesions observed during treatment.

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Abstract not available — see full article for details.

Early pars plana vitrectomy in a case of presumed postoperative endophthalmitis revealed intraoperative findings diagnostic of vancomycin-associated hemorrhagic occlusive retinal vasculitis (HORV), enabling cessation of intravitreal antibiotics and resulting in recovery of visual acuity to 20/30.