RetinaDigest

Abstract not available — see full article for details.

Intraoperative mitomycin-C (MMC) during PPV for recurrent rhegmatogenous retinal detachment with PVR showed a trend toward improved anatomical outcomes (83.3% vs. 70.0% primary success) and lower PVR recurrence compared to controls, though differences did not reach statistical significance.

In this retrospective cohort of 235 eyes undergoing PPV for primary inferior RRD, endolaser retinopexy achieved significantly higher single-surgery anatomical success (83.3%) compared to cryotherapy (64.6%), with higher PVR grade and a break at 6 o'clock independently associated with failure.

Post-traumatic choroidal rupture primarily affects young males with submacular involvement, and while choroidal neovascularization develops in nearly half of cases within weeks of injury, it responds well to a limited course of anti-VEGF therapy with meaningful visual recovery.

Abstract not available — see full article for details.

In this multicenter retrospective cohort study of 2,755 Greater Toronto Area patients with PDR or DME, limited subway proximity—including greater distance, more stops, required transfers, and longer travel times—was independently associated with significantly increased odds of being lost to follow-up.

Unsupervised clustering of OCT and functional variables in chronic CSC identified three structural phenotypes—pachychoroid-dominant, transitional, and degenerative—with visual recovery after PDT governed primarily by photoreceptor status rather than choroidal thickness, while a distinct choroidal dimension separates otherwise equivalent eyes by subfoveal choroidal thickness and age.

Abstract not available — see full article for details.

In a prospective Asian cohort with geographic atrophy, baseline GA area, multifocality, and subretinal drusenoid deposits independently predicted faster GA growth, while deep learning-derived photoreceptor degeneration extending beyond established atrophy provided modest incremental prognostic value over conventional predictors.

Massive submacular hemorrhage causes acute, irreversible neurosensory retinal thinning (mean FSRT reduction from 193.5 to 107.0 μm), with pre-onset visual acuity and retinal integrity emerging as key determinants of post-surgical outcomes following subretinal tPA injection.

In treatment-naïve BRVOME eyes, baseline inter-eye superficial FAZ disparity (ΔSCP) — rather than longitudinal FAZ enlargement — independently predicts recurrence burden, with each 0.1-mm² increase in ΔSCP associated with an 8% higher anti-VEGF injection requirement over 12 months.

In a matched retrospective cohort study of over 10,000 RVO patients, comorbid obstructive sleep apnea (OSA) was associated with significantly increased risk of venous thromboembolism and myocardial infarction following RVO, identifying OSA as a clinically important modifier of systemic thromboembolic risk in this population.

This large multicenter South Korean cohort study of 126 patients with EYS-associated retinal degeneration demonstrates linear structural decline with ellipsoid zone width loss of ~124 µm/year (~4.6%/year) and visual acuity deterioration of 0.043 logMAR/year, with no significant genotype-phenotype correlation.

Prophylactic cryotherapy using the Cambridge protocol significantly reduces retinal detachment risk in type 2 Stickler syndrome, with treated patients showing a 3.3- to 5.7-fold lower hazard of detachment compared to untreated controls, and no serious long-term adverse effects.

In this long-term retrospective study of lens-sparing vitrectomy (LSV) for advanced ROP, favorable visual acuity (≥20/200) was achieved in 53.8% of stage 4A and 16.7% of stage 4B eyes, while no stage 5 eye attained letter-reading vision despite anatomical reattachment in 60% of cases.

In this small retrospective series of 11 patients with refractory non-infectious uveitis, scleritis, or idiopathic orbital inflammatory syndrome, rituximab achieved a 90.9% response rate and an 87.7% reduction in daily corticosteroid dose, supporting its role as a steroid-sparing agent across heterogeneous ocular inflammatory conditions.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

Adalimumab monotherapy achieved sustained control of IRVAN syndrome over five years in a 46-year-old male who failed corticosteroids, azathioprine, and cyclosporine, with disease relapse upon dose tapering and re-stabilization after resuming biweekly dosing.

This scoping review with transcriptomic analysis found consistent associations between vitamin D deficiency and increased risk or severity of noninfectious uveitis (NIU), with genetic polymorphisms in vitamin D metabolism genes and dysregulation of innate immune pathways potentially contributing to disease susceptibility.

Abstract not available — see full article for details.

A 36-year-old unvaccinated male developed asynchronous bilateral macular necrotizing measles retinitis with characteristic OCT findings; diagnosis required clinical integration when PCR testing was non-diagnostic, and a combined antiviral regimen preserved central vision.

This multi-centre retrospective study of 53 patients with serologically confirmed Bartonella-associated uveitis demonstrates that non-neuroretinitis phenotypes are common, comprising 50% of presentations, underscoring the need to consider Bartonella across a broad spectrum of posterior segment inflammatory disease.

This familial case series of ALPK1 p.Thr237Ala-associated ROSAH syndrome demonstrates marked intrafamilial phenotypic variability, with tocilizumab (IL-6 inhibition) effectively controlling systemic inflammation and early ocular disease but failing to reverse established retinal degeneration and profound visual loss.

This study identified four distinct fundus autofluorescence (FAF) distribution patterns in MEWDS—diffuse, peripapillary, placoid-like, and peripheral sectorial—demonstrating that diffuse FAF involvement is most characteristic of primary MEWDS, while placoid-like and peripheral sectorial patterns should raise suspicion for infectious etiologies, particularly ocular syphilis.

Choroidal involvement in nodal marginal zone lymphoma can masquerade as inflammatory choroiditis with steroid-responsive but recurrent serous retinal detachment; systemic workup with biopsy of accessible extraocular lesions can establish diagnosis without high-risk choroidal biopsy.

Abstract not available — see full article for details.

This case series documents spontaneous regression of vitreoretinal lymphoma (VRL) lesions in five biopsy-confirmed patients, observed across multiple lesion subtypes and occurring both in treatment-naïve patients and those under post-treatment surveillance, possibly mediated by immune mechanisms triggered by diagnostic vitrectomy.

In this retrospective series of 49 VRL patients, disease-specific survival was primarily driven by systemic and CNS involvement rather than diagnostic delay, with choroidal infiltrates associated with lower CNS dissemination risk and a trend toward improved survival.

A stepwise multimodal treatment approach for conjunctival melanocytic lesions achieved satisfactory local disease control across the spectrum from low-grade CMIL to invasive melanoma, with non-bulbar involvement and residual pigmentation emerging as the strongest independent predictors of local recurrence.

In a propensity score-matched real-world cohort of 7,194 pairs, intravitreal anti-VEGF therapy was associated with significantly higher risks of major adverse kidney events, CKD progression, and dialysis compared to untreated controls, though absolute risk differences were small.

In a large IRIS Registry study of 1,275 post-PPV endophthalmitis cases, intravitreal antibiotics alone (without repeat vitrectomy) were used in 80.9% of cases, with no significant difference in long-term visual or anatomic outcomes compared to repeat PPV, though overall globe loss occurred in 16.1% of eyes.