RetinaDigest

A cumulative risk scoring system using three factors—vitreous hemorrhage, multiple retinal tears, and subretinal fluid adjacent to the tear—stratifies the likelihood of requiring additional retinal intervention after laser retinopexy, with rates ranging from 0.6% (zero factors) to 100% (all three factors present).

This systematic review and meta-analysis of 5,084 fellow eyes found that prophylactic retinopexy was associated with a 57% reduction in retinal detachment risk in fellow eyes following contralateral RD (RR 0.43; 95% CI, 0.33–0.57), though overall evidence certainty was rated Low by GRADE.

An international Myopia Society expert panel established a new OCT-based hierarchical nomenclature for myopic traction maculopathy (MTM), ranking four primary manifestations by severity: macular detachment, full-thickness macular hole, lamellar macular hole, and retinoschisis.

A viscoelastic-supported temporal inverted ILM flap technique with air tamponade alone achieved 100% macular hole closure in 78 eyes without requiring gas endotamponade or postoperative head positioning, yielding significant visual acuity improvement.

In this multicenter U.S. cohort of 36 genetically confirmed Knobloch syndrome patients, retinal detachment occurred in 31.9% of eyes, and prophylactic laser or scleral buckle treatment was associated with significantly lower odds of RD (OR 0.20, p=0.022), supporting early intervention in this high-risk population.

Abstract not available — see full article for details.

In a large retrospective propensity score-matched cohort study, common anti-inflammatory medications—cetirizine, ibuprofen, and prednisone—were each associated with 38–64% reductions in incident diabetic macular edema and proliferative diabetic retinopathy in adults with type 2 diabetes, with effect sizes comparable to the established positive control fenofibrate.

In a 2-year real-world case series, intravitreal pegcetacoplan reduced geographic atrophy growth rate by 41% compared to pre-treatment rates, with efficacy continuing to accumulate through the second year of treatment.

Abstract not available — see full article for details.

In intermediate AMD, ribbon-type reticular pseudodrusen (RPD) is associated with greater retinal sensitivity loss than dot-type RPD, and the combination of ribbon-type RPD with soft drusen confers the greatest longitudinal decline in retinal sensitivity.

Abstract not available — see full article for details.

Polysomnography (PSG) identified obstructive sleep apnea (OSA) in 85.71% of newly diagnosed RVO patients, compared to only 8.16% identified by prior medical history, suggesting RVO should prompt routine sleep apnea evaluation.

This case report describes cilioretinal-sparing CRAO in an 11-year-old girl with ADA2 deficiency and polyarteritis nodosa-like vasculitis, highlighting ADA2 deficiency as an important monogenic cause of retinal arterial occlusion in pediatric patients.

A novel EFEMP1 variant (p.Arg140Trp) causes a late-onset, predominantly peripheral retinal degeneration with preferential rod involvement, a phenotype distinctly different from the central drusen-dominant presentation of classic Doyne honeycomb retinal dystrophy/malattia leventinese caused by p.Arg345Trp.

This systematic review and meta-analysis found that adjunctive intravitreal anti-VEGF therapy combined with ablative treatment for Coats disease reduces the number of treatment sessions required to achieve quiescence, while achieving comparable anatomical and functional outcomes without significantly increasing the risk of tractional retinal detachment.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

In a real-world retrospective study of 275 eyes treated with the 0.18 mg fluocinolone acetonide implant (FAi) for non-infectious posterior uveitis, ocular hypertension occurred in only 10.5% of eyes, with higher baseline IOP and pre-existing IOP-lowering medication use identified as the strongest predictors of post-implant pressure elevation.

Multimodal imaging in chronic, clinically inactive VKH disease reveals a consistent spectrum of structural alterations—most commonly granular FAF patterns, peripapillary hypoautofluorescence, and IR hyperreflective spots—with specific FAF findings correlating with disease duration, suggesting cumulative structural remodeling even in the absence of clinical inflammation.

Abstract not available — see full article for details.

This systematic review of 14 studies demonstrates that suprachoroidal triamcinolone acetonide (CLS-TA) consistently improves visual acuity (+7 to +16 ETDRS letters) and reduces central macular thickness (152–200 µm) in noninfectious uveitic macular edema, with a favorable safety profile including low rates of clinically significant IOP elevation (<10% in controlled trials).

Among 4,578 adults with diabetic retinopathy, retinal vein occlusion, or exudative AMD in the All of Us Research Program, racial and ethnic minority patients reported significantly greater barriers to retinal care—including transportation, cost, childcare, and discrimination—with the most pronounced disparities occurring in diabetic retinopathy.