RetinaDigest

This narrative review synthesizes evidence supporting a biomarker-guided framework integrating OCT and OCTA-derived imaging markers with pharmacologic and surgical decision-making to enable personalized, precision-based management of vitreoretinal diseases.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

In this multicenter retrospective study of 379 eyes with GRT-related retinal detachment, PPV combined with scleral buckle improved 6-month single-surgery anatomic success in phakic eyes (95.4% vs 83.1%), while prophylactic laser treatment did not reduce the risk of fellow eye GRT or retinal detachment over a mean follow-up of 2.8 years.

Abstract not available — see full article for details.

In this retrospective study of 110 PDR patients undergoing PPV, impaired renal function was associated with worse baseline ocular and systemic disease but was not an independent predictor of visual outcomes; longer diabetes duration and lower serum albumin were the key independent risk factors for poorer visual prognosis.

Abstract not available — see full article for details.

In a cross-sectional study of 833 eyes with type 2 diabetes, temporal sector pRNFL thickening—but not global pRNFL thickness—was independently associated with diabetic retinopathy severity, suggesting it may serve as a regional structural biomarker of diabetic neuroaxonal injury.

A YOLOv11-based deep learning model trained on 6,215 OCT B-scans achieved up to 84% mAP and 85% F1-score for detecting and localizing myopic macular neovascularization, demonstrating reliable performance even in structurally complex eyes with coexisting pathologic myopia findings.

Three distinct geographic atrophy (GA) phenotypes—unifocal foveal-involving, large coalescing multifocal, and small numerous multifocal—demonstrate significantly different growth trajectories, with multifocal phenotypes and concomitant peripapillary involvement portending more aggressive disease progression.

A retinal surgeon in Guangzhou, China successfully performed robotic-assisted subretinal injection of tPA for submacular hemorrhage in a patient located approximately 4000 km away in Urumqi, demonstrating proof-of-concept feasibility and safety of ultra-long-distance ophthalmic telesurgery.

OcularChat, an AMD-specific multimodal large language model fine-tuned on nearly 46,000 AREDS fundus images and over 700,000 simulated clinical dialogues, demonstrated strong performance in classifying advanced AMD (95.4%) and was rated superior to its non-fine-tuned counterpart by retina specialists.

In the PINNACLE study, lesion-centered microperimetry revealed that retinal sensitivity begins declining before OCT-detectable ellipsoid zone/interdigitation zone loss in intermediate AMD, with foveal locations carrying the greatest risk of significant sensitivity loss.

Abstract not available — see full article for details.

In a large UK Biobank cohort of over 361,000 participants, metabolic syndrome (MetS) was independently associated with a 59% increased risk of retinal artery occlusion (RAO), with hypertension and hyperglycemia emerging as the strongest individual contributors, and genetic predisposition to type 2 diabetes further amplifying this risk.

In a UAE cohort of 24 Emirati patients with non-syndromic adult-onset rod-cone dystrophy, autosomal recessive inheritance predominated (89%), with PCARE being the most common causative gene and a likely founder variant identified; atypical early macular involvement strongly predicted CDHR1 or CERKL variants.

Clinicopathologic analysis of three donor eyes with genetically confirmed ADNIV reveals early choroidal lymphocytic infiltration and Müller cell gliosis with preserved RPE across disease stages, suggesting pathogenesis is driven by altered CAPN5 protease activity rather than changes in protein abundance or localization.

Abstract not available — see full article for details.

This multicenter study of 22 patients with telomere biology disorders (TBDs) found universal retinovascular abnormalities on widefield fluorescein angiography, proposing the term 'Short Telomere Associated Retinopathy (STAR)' and a staging system to guide management.

Abstract not available — see full article for details.

In VZV-induced acute retinal necrosis, higher baseline aqueous viral loads and elevated IL-8 levels correlate with worse visual outcomes, and IL-8 demonstrates greater sensitivity than viral load as an early marker of antiviral treatment response.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

This report describes only the second documented case of retinal metastasis from urothelial carcinoma of the bladder, confirmed via pars plana vitrectomy biopsy with immunohistochemical markers including uroplakin III and GATA-3 positivity.

Abstract not available — see full article for details.

In this large series of 4000 eyes treated with plaque radiotherapy for posterior uveal melanoma in the pre-anti-VEGF era, higher radiation doses to the optic disc and foveola were significantly associated with greater rates of ≥15-letter visual acuity loss.

A FAERS database analysis (2020–2025) identified 554 retinal vasculitis adverse events (RVAEs) across FDA-approved intravitreal anti-VEGF and complement inhibitor agents, with brolucizumab accounting for the largest proportion (56.1%), followed by faricimab (16.4%) and pegcetacoplan (11.9%).

In a simulator-based study of 10 experienced vitreoretinal surgeons, intraoperative distractions significantly impaired surgical performance and prolonged task completion time, while brief pre-task meditation showed limited benefit.

In this retrospective comparative study of 179 eyes, transscleral four-point fixation with a closed continuous-loop suture demonstrated a significantly lower risk of IOL redislocation compared to the Yamane technique (HR 8.68), despite both methods yielding equivalent visual and refractive outcomes at 6 months.