RetinaDigest

This systematic review and meta-analysis of 69 studies found no significant improvement in anatomical outcomes with any individual pharmacologic agent for PVR prevention or treatment, though methotrexate, anti-VEGF agents, and retinoids showed promising signals warranting further investigation.

Posterior segment curvature, measured as the radius of curvature of Bruch's membrane (rBM) on OCT, differs significantly between eyes with macular holes and rhegmatogenous retinal detachment independent of axial length, suggesting globe shape determines whether vitreoretinal traction manifests centrally or peripherally.

The Luca™ telemanipulated robotic system demonstrated a favorable safety and feasibility profile for core vitrectomy in ERM and macular hole surgery, with no device-related adverse events and successful task completion in 6 of 7 patients.

In patients with unilateral epiretinal membrane, dominant eye involvement produces greater binocular metamorphopsia and stronger correlation with vision-related quality of life, with a monocular metamorphopsia score ≥0.55 identified as a threshold for binocular symptom perception.

A case series of 19 patients with zone 3 perforating globe injuries demonstrated that combining amniotic membrane coverage of the exit wound with early pars plana vitrectomy achieved 89.5% retinal reattachment, 100% globe survival, and visual improvement in 89.5% of patients at 6 months.

Central retinal vessel trunk (CRVT) dragging is a common finding in highly myopic eyes, with prevalence rising dramatically from 0% in eyes ≤25.0mm axial length to 72.2% in eyes >28.0mm, driven primarily by increased fovea-disc distance from axial elongation.

In this retrospective series of 12 eyes undergoing PPV for PDR complicated by asteroid hyalosis, 91.7% achieved anatomic success at a mean follow-up of 10.7 months, demonstrating that favorable outcomes are achievable despite increased intraoperative complexity.

In a large retrospective propensity score-matched cohort study, systemic IL-6 inhibitor use was associated with significantly reduced 5-year risks of incident diabetic retinopathy, DR progression, DME, vitreous hemorrhage, and need for retinal interventions compared to matched diabetic controls.

In this 5-year retrospective series of AMD eyes with RPE tears, approximately half developed tear-associated RPE proliferation (TARP), but this anatomical remodeling did not translate into improved visual outcomes, with overall BCVA declining significantly in both groups.

In a longitudinal cohort of 42 eyes with drusenoid PED, baseline choriocapillaris flow deficit (CCFD) and its rate of progression independently predicted both geographic atrophy development and final visual acuity, underscoring choroidal hemodynamic dysfunction as a key driver of AMD progression.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

In a nationwide South Korean cohort of over 462,000 cancer survivors, both retinal artery occlusion (RAO) and retinal vein occlusion (RVO) occurred at significantly higher rates than in the general population, with hematologic malignancies conferring the greatest risk for RAO and eye/adnexa cancers carrying the highest risk for RVO.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

Adalimumab significantly reduced treatment burden in patients with multifocal choroiditis/punctate inner choroidopathy, achieving near-complete steroid elimination and dramatic reductions in anti-VEGF injections and supplemental immunomodulatory therapy while preserving vision over a mean follow-up of 51 months.

Abstract not available — see full article for details.

An international Delphi consensus panel of 27 experts established standardized definitions for 8 key retinal vasculitis-related terms, achieving >95% agreement in the second round to harmonize clinical and research terminology.

En face OCT-guided navigated focal laser photocoagulation achieved non-inferior outcomes compared to conventional FA-guided treatment in non-resolving CSCR, with SRF resolution rates of 84.6% vs. 81.3% at 3 months, suggesting FA may not be required for laser planning.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

In a large propensity-matched cohort study, endogenous endophthalmitis from candidal sepsis was associated with significantly lower rates of retinal detachment and vitreoretinal intervention compared to bacterial sepsis, despite carrying higher one-year all-cause mortality.