RetinaDigest

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This large IRIS Registry analysis of over 1.1 million DR patients found that urban practices performed 65–99% of all diabetic retinopathy procedures even after adjusting for population and disease burden, highlighting a critical geographic disparity in DR care access across the United States.

Hyperreflective abnormal areas (HAAs) in the middle retinal layers on en face OCT significantly improved discrimination of referable diabetic retinopathy beyond established clinical risk factors, suggesting their potential as a structural biomarker for identifying high-risk diabetic eyes without center-involving DME.

In this retrospective cohort study of 31 patients with co-existing GA and nAMD, adding pegcetacoplan to ongoing anti-VEGF therapy was associated with a 44% reduction in GA growth rate over one year, while visual acuity remained stable.

Multimodal imaging reveals distinct Bruch's membrane (BrM) biomarkers—including higher BrM reflectivity index (BRI) and more frequent BrM undulation—in angioid streak-associated MNV compared to neovascular AMD, potentially reflecting BrM calcification and mechanical instability.

A 22-year-old woman developed a delayed subfoveal CNVM nine months after apparent recovery from unilateral acute idiopathic maculopathy (UAIM), ultimately requiring combined anti-VEGF and systemic corticosteroid therapy to achieve disease control and improve vision from 6/30 to 6/12.

A 28-year-old man presented with sequential cilioretinal artery occlusion and acute anterior uveitis as the dual initial manifestation of newly diagnosed SLE, likely representing concurrent occlusive and inflammatory expressions of the same active disease rather than a causal sequence.

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A retrospective OCT and fundus photography analysis of 33 genetically confirmed XLRS patients found cystoid spaces in 100% of gradable eyes and macular schisis in 87.5%, with clinically significant inter-eye asymmetry observed across multiple imaging features.

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Abstract not available — see full article for details.

A 64-year-old man with CLL developed recurrent bilateral granulomatous panuveitis and systemic sarcoidosis-like reactions associated with ibrutinib, which recurred within 8 days of switching to the next-generation BTK inhibitor pirtobrutinib, suggesting a potential class-effect immune mechanism.

This case series of six pediatric sarcoidosis patients demonstrates that childhood-onset sarcoidosis (COS) frequently presents with aggressive, bilateral granulomatous uveitis with posterior segment involvement, requiring early systemic immunosuppression and vigilant ophthalmic monitoring to prevent vision loss.

Bilateral acute retinal necrosis (BARN) represented 12.8% of ARN cases at a South Indian tertiary center, carrying a severe prognosis with significant visual morbidity, frequent retinal detachment, and poor final visual acuity over a mean follow-up of 38 months.

In Cushing's syndrome patients, widefield SS-OCTA revealed significantly increased choroidal thickness, choroidal vascular index, and deep capillary plexus vessel density compared to healthy controls, with choroidal parameters positively correlating with endogenous cortisol levels and reversing after adrenalectomy.

In this prospective case-control study, IBD patients demonstrated significantly increased parafoveal vessel density in both superficial and deep capillary plexuses and greater choriocapillaris blood flow area on OCTA compared to healthy controls, suggesting systemic inflammatory vasodilation as a measurable ocular manifestation of the gut-retina axis.