RetinaDigest

A novel OCT finding called marginal outer retinal ridge (MORR) was identified following rhegmatogenous retinal detachment repair, serving as a biomarker for retinal displacement and redundancy.

A 7-year-old male with X-linked congenital retinoschisis developed bilateral exudative retinal detachment and elevated IOP secondary to combined H1N1 influenza and Mycoplasma infection, which resolved with appropriate antimicrobial therapy.

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Unhoused diabetic patients present with significantly more advanced diabetic retinopathy and vision-threatening complications compared to housed patients, with markedly reduced follow-up rates despite increased need for care.

Eyes with peripapillary pachychoroid syndrome show significantly increased temporal scleral thickness and 60% prevalence of ciliochoroidal effusion compared to healthy controls, suggesting scleral anatomy may be a predisposing factor.

Asian patients with type 3 macular neovascularization present at younger ages with lesions located significantly closer to the foveal center compared to Caucasian patients, suggesting ethnic variations in disease presentation patterns.

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Microperimetry-based endpoints detected functional improvement in 45-64% of RPGR gene therapy patients compared to only 20% with low luminance visual acuity, demonstrating superior sensitivity for treatment efficacy detection.

A modified two-port, vitrectomy-free subretinal injection technique for gene therapy in Bietti crystalline dystrophy demonstrated safety and feasibility with no intraoperative complications and potential reduction in cataract risk.

An optimized AAV5-RPGR gene therapy vector demonstrated significant preservation of photoreceptor structure and function in a mouse model of X-linked retinitis pigmentosa, with dose-dependent efficacy and favorable safety profile.

Two-port non-vitrectomy endolaser therapy (TPNVE) achieved 100% anatomic success in 47 eyes with moderate-to-severe stage 3A Coats disease, with 42.5% requiring only one treatment session.

This case report describes successful treatment of concurrent Toxoplasma gondii retinochoroiditis and Epstein-Barr virus retinal necrosis in an immunocompetent patient using intravitreal methotrexate combined with systemic antiviral therapy.

A 5-year retrospective study of 16 eyes with acute retinal necrosis found that 44% developed retinal detachment despite intensive intravitreal antiviral therapy, with half achieving final visual acuity worse than 20/200.

A 23-year-old male with chronic unilateral uveitis developed PCR-confirmed Listeria monocytogenes necrotizing chorioretinitis with secondary macular hole, initially misdiagnosed as viral hypertensive uveitis.

Anti-adalimumab antibodies develop in nearly 50% of patients with inflammatory ocular diseases by 8 years of therapy, leading to lower drug levels and increased risk of active ocular inflammation.

In this retrospective study of 28 APMPPE cases, 21.4% experienced recurrence, with 5 of 6 recurrent cases ultimately requiring diagnostic revision to ocular tuberculosis and anti-TB therapy for resolution.

A 45-year-old male developed autoimmune retinopathy with systemic manifestations including alopecia areata and vitiligo, with onset temporally associated with COVID-19 vaccination, responding to immunosuppressive therapy with mycophenolate mofetil.

In a Korean cohort of 687 patients referred for suspected uveal melanoma, 82.1% had pseudomelanomas rather than true melanoma, with distinct age-specific diagnostic patterns observed across different conditions.

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