RetinaDigest

This prospective case series of 20 highly myopic eyes demonstrated 100% macular hole closure at 12 weeks using ILM flap technique without gas tamponade, with significant visual improvement and median closure time of 1 week.

This scoping review of 603 eyes across 66 studies demonstrates that human amniotic membrane grafts achieve 96% macular hole closure rates with 81% visual improvement and minimal complications when used as an adjunct to standard pars plana vitrectomy and ILM peeling.

Thin-choroid CSCR represents a distinct phenotype affecting older females with similar visual outcomes but significantly higher risk of choroidal neovascularization development compared to typical thick-choroid CSCR.

Large high myopic macular holes (≥400 μm) achieved 72.4% closure rates at 3 months with various surgical techniques, with meaningful visual acuity improvements regardless of surgical approach used.

This systematic review and meta-analysis of 26 studies (18,724 eyes) found that AI-based models demonstrated pooled sensitivity of 89% and specificity of 87% for predicting vitreoretinal surgical outcomes, with most studies showing AI outperformance compared to conventional statistical approaches.

This multicenter study identified distinct OCT-based imaging biomarkers that can differentiate Candida from Aspergillus endogenous fungal endophthalmitis with ~85% accuracy, potentially enabling earlier targeted antifungal therapy while awaiting culture results.

Fellow eyes of patients with central retinal artery occlusion show a significantly higher prevalence of retinal ischemic perivascular lesions (74.4% vs 24.6% in controls), suggesting subclinical microvascular changes detectable by SD-OCT.

Post hoc analysis of three aflibercept phase 3 trials demonstrated that earlier treatment initiation (within 1 month of diagnosis) and worse baseline visual acuity were associated with greater visual gains in patients with macular edema secondary to retinal vein occlusion.

This nationwide Japanese cohort study of 34 patients demonstrates that RPGRIP1 variants cause two distinct phenotypes - Leber congenital amaurosis (LCA) with severe early vision loss and achromatopsia (ACHM) with better preserved vision, with clear genotype-phenotype correlations based on variant location.

A 46-year-old female carrier of X-linked RP2 retinopathy developed secondary punctate inner choroidopathy (PIC), which was successfully managed with immunosuppressive therapy including biologics.

Researchers developed sex-specific clinical prediction models for treatment-requiring retinopathy of prematurity (TR-ROP) that achieved high accuracy without requiring fundus photography, potentially reducing unnecessary screening examinations.

In patients with chronic non-infectious uveitis achieving steroid-sparing control, combination therapy with conventional immunomodulatory therapy plus TNF-α inhibitors significantly reduced flare rates compared to conventional therapy alone over 24 months.

Swept-source OCT reveals distinct structural signatures across toxoplasmic retinochoroiditis phases, with active disease showing retinal edema and vitreous changes, reactive phases exhibiting transitional remodeling, and inactive disease manifesting chronic atrophy and ellipsoid zone disruption.

Several disease-modifying therapies for multiple sclerosis, particularly nucleic acid synthesis inhibitors/S1P modulators and fumarates, significantly reduce the risk of non-infectious uveitis compared to glatiramer acetate.

In a multicenter cohort of 409 sarcoid uveitis patients, the modified Abad criteria demonstrated the highest sensitivity (99.3%) compared to IWOS (90.1%) and SUN criteria (83.4%) for diagnosing sarcoid uveitis.

Three patients developed bilateral cerebriform retinitis with outer retinal necrosis following mumps parotitis, with hyperbaric oxygen therapy showing more promising results than systemic steroids alone.

This retrospective case series characterizes tubercular retinitis (TBR) as a rare phenotype of ocular tuberculosis affecting purely retinal layers, distinct from tubercular retinochoroiditis, with characteristic imaging features and healing patterns.

This retrospective study of 31 eyes with pediatric uveitic macular edema found significant visual and anatomical improvement with contemporary immunomodulatory therapy, with early visual acuity and photoreceptor integrity predicting long-term outcomes.

In a tertiary uveitis center cohort, 4% of Behçet uveitis patients developed Neuro-Behçet's syndrome during follow-up, with parenchymal involvement being most common and neurological symptoms often occurring independently of ocular inflammatory activity.

This systematic review of 262,716 patients found that 23% of new-onset uveitis cases occur in patients aged 60 and above, with masquerade syndromes accounting for only 4.9% of cases, challenging the common assumption that uveitis in older adults is primarily due to malignancy.

This systematic review and meta-analysis of 2,411 patients from 41 studies found that IL-10/IL-6 ratio demonstrates excellent diagnostic performance for primary vitreoretinal lymphoma (PVRL), with parallel testing of IL-10/IL-6 and MYD88 achieving optimal sensitivity (97.1%) and specificity (97.0%).