RetinaDigest

Exudative retinal detachments (ERDs) are a rare but important finding in acute retinal necrosis (ARN), signaling extensive inflammation, high rates of occlusive vasculitis, and a 50% risk of subsequent rhegmatogenous retinal detachment.

Iris manipulation (mechanical pupillary expansion or synechiolysis) during phacovitrectomy for retinal detachment (RD) repair is significantly associated with an increased risk of developing proliferative vitreoretinopathy (PVR), even in the absence of active inflammation.

The AI system Verisee accurately detected referable diabetic retinopathy (RDR) in a real-world setting but showed reduced performance in older patients and missed other significant ocular conditions such as glaucoma.

This study found no evidence of faster diabetic retinal disease (DRD) progression in younger patients (≤25), contrary to recent reports. Instead, patients aged ≥65 showed significant declines in DRD prevalence and incidence, including vision-threatening components like PDR, over the two-decade observation period.

This comprehensive review links traditional combustible cigarette smoking to a broad spectrum of ocular diseases, identifying oxidative stress, inflammation, and neovascularization as key underlying mechanisms, and underscores smoking cessation as a critical preventive strategy.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

Deletion involving exon 18 of RPGRIP1 (RPGRIP1-ex18-DEL) is a major genetic cause of achromatopsia in Japanese patients, presenting with a stable phenotype comparable to other common genetic causes.

Mucopolysaccharidosis type III (MPS III) patients frequently present with parafoveal outer retinal degeneration and foveal external limiting membrane thickening, with MPS IIIA subtype showing more severe retinal involvement.

This systematic review and meta-analysis suggests that spherical equivalent refraction (SER) is a more comprehensive primary metric for monitoring childhood myopia progression and assessing overall disease risk (cataract, POAG, retinal pathology), while axial length (AL) is best for identifying the small minority of very long eyes at extreme retinal risk.

Concurrent intraocular infection with *Mycobacterium tuberculosis* complex (MTBC) and non-tuberculous mycobacteria (NTM) causes a distinct, aggressive panuveitis with severe sequelae, but effectively resolves with standard anti-tubercular therapy (ATT).

Optical coherence tomography angiography (OCTA) reveals a significant reduction in deep capillary plexus vessel density (DCP-VD) in patients with sarcoidosis, even in those without clinical ocular involvement, suggesting subclinical microvascular compromise.

Abstract not available — see full article for details.

Patients with pseudoexfoliation glaucoma (PXG) have a significantly increased hazard of developing central serous chorioretinopathy (CSCR) compared to those with primary open-angle glaucoma (POAG).

Age at diagnosis refines genetic risk stratification for metachronous bilateral conversion in initially unilateral retinoblastoma, identifying a very low-risk subgroup among RB1 variant-positive patients diagnosed at 9 months or older who may warrant deescalated surveillance.

Abstract not available — see full article for details.

Uveitis is a recognized, albeit uncommon, side effect of 18 FDA-approved protein kinase inhibitors (PKIs), with vemurafenib being the most frequently implicated agent. Early diagnosis, interdisciplinary management, and subtype-specific treatment strategies are essential to mitigate visual morbidity and support continuation of oncologic therapy.

Abstract not available — see full article for details.

Long-term intravitreal anti-VEGF injections significantly increase the risk and accelerate the development of cataract requiring surgical intervention compared to untreated fellow eyes.

Abstract not available — see full article for details.

Intravitreal anti-VEGF utilization among Medicare beneficiaries significantly increased from 2014-2023, primarily driven by aflibercept growth and rapid faricimab adoption, while reimbursement for branded agents declined and substantial geographic variation persisted.

Silicone oil (SO) droplet transmission during anti-VEGF injections is a recognized issue, often linked to syringe factors and handling, but serious complications are rare, and it can be minimized by optimizing syringe design, storage, and injection techniques.