RetinaDigest

Weekly curated literature from top retina and ophthalmology journals

17 articles
6 categories
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Retinal Detachment & Trauma1 article

RRD, TRD, giant tears, PVR, ocular trauma, macular hole, ERM

Epiretinal Proliferation Embedding Surgery Combined with Temporal Inverted ILM Flap Technique for Lamellar Macular Holes.

Avcı … Yılmaz
RetinaMar 3, 2026

Pars plana vitrectomy combined with epiretinal proliferation (EP) embedding and temporal inverted ILM flap technique yielded 100% anatomical closure and significant visual improvement in lamellar macular holes (LMH), with better outcomes linked to earlier intervention.

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AMD & Macular Degeneration4 articles

Neovascular AMD, geographic atrophy, submacular hemorrhage

AMD Risk in Users of GLP-1RAs and Other Weight-Loss Drugs.

Mihalache … Popovic
JAMA OphthalmolMar 5, 2026

Abstract not available — see full article for details.

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AMD Risk in Users of GLP-1RAs and Other Weight-Loss Drugs-Reply.

Ahuja … Young
JAMA OphthalmolMar 5, 2026

Abstract not available — see full article for details.

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Associations Between Systemic Tyrosine Kinase Inhibitors and Development of Age-Related Macular Degeneration in Patients with Cancer.

Wu … Singh
Ophthalmol RetinaMar 4, 2026

Systemic tyrosine kinase inhibitors (TKIs) were not consistently associated with a reduced risk of incident age-related macular degeneration (AMD) diagnosis in cancer patients; however, TKIs with anti-VEGF activity showed a reduced risk at 5 years.

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Long-term Efficacy and Safety of Photobiomodulation in Dry Age-Related Macular Degeneration (LIGHTSITE III: 24-Month Analysis).

Jaffe … Tedford
RetinaMar 3, 2026

Multiwavelength photobiomodulation (PBM) significantly improved BCVA and reduced geographic atrophy progression over 24 months in dry AMD, demonstrating both visual function restoration and potential disease modification.

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Vascular Occlusions1 article

CRVO, BRVO, retinal ischemia, macular edema from RVO

Risks of Retinal Vascular Occlusions with the Systemic Use of Tyrosine Kinase Inhibitors.

Jeong … Talcott
Ophthalmol RetinaMar 4, 2026

Systemic anti-VEGF tyrosine kinase inhibitors (TKIs) are associated with a nearly threefold increased hazard of central retinal vein occlusion (CRVO) within three years of treatment initiation, while non-anti-VEGF TKIs may have a more favorable retinal vascular occlusion safety profile.

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Posterior Uveitis5 articles

Posterior uveitis, panuveitis, chorioretinitis, CMV retinitis, ocular inflammation

Incidence of Cataract Surgery and Postoperative Visual Acuity Outcomes in Patients with Vogt-Koyanagi-Harada Disease.

Sittivarakul … Ratanasukon
Ocul Immunol InflammApr 1, 2026

Patients with Vogt-Koyanagi-Harada (VKH) disease have a moderate risk of developing visually significant cataracts requiring surgery, which leads to substantial and sustained visual acuity improvement, especially in those on systemic immunomodulatory treatment.

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Unilateral Multifocal Choroiditis in HTLV-1 Infection.

Isik … Ouamrane
JAMA OphthalmolMar 5, 2026

Abstract not available — see full article for details.

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Acute Posterior Multifocal Placoid Pigment Epitheliopathy Spectrum on Multimodal Imaging: A Severity-Driven Ischemic Continuum.

De Simone … Cimino
Ocul Immunol InflammMar 5, 2026

This study describes a severity-graded continuum for Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) spectrum disease, identifying 'peripheral APMPPE' as a novel intermediate phenotype between classic APMPPE and ampiginous choroiditis based on multimodal imaging features.

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Incidence and Prevalence of Non-Infectious Uveitis: A Systematic Review and Meta-Analysis.

Sriranganathan … Felfeli
RetinaMar 3, 2026

This systematic review and meta-analysis estimates the pooled incidence and prevalence of non-infectious uveitis (NIU), finding higher rates in adults and significantly increased risk in patients with specific systemic inflammatory conditions like JIA, SpA, PsA, AS, and BD.

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Risk Factors for Long COVID Among Individuals with Noninfectious Uveitis in a Large United States Claims Database.

Kumar … Acharya
Ocul Immunol InflammMar 3, 2026

Patients with noninfectious uveitis (NIU) on systemic corticosteroids face a significantly increased risk of developing long COVID, while COVID-19 vaccination is associated with a decreased risk.

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Ocular Oncology1 article

Uveal melanoma, retinoblastoma, choroidal tumors, ocular metastases

A Case of Adenocarcinoma of the Retinal Pigment Epithelium.

Lin … Chou
OphthalmologyMar 4, 2026

Abstract not available — see full article for details.

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Complications & Safety5 articles

Endophthalmitis, surgical complications, drug safety, adverse events

Clinical Features Associated with Poor Prognosis in Endogenous Endophthalmitis: New Insights from a 5-Year Retrospective Study.

Teoh … Rahmat
Ocul Immunol InflammApr 1, 2026

Swollen eyelids, ocular pain, and *Klebsiella pneumoniae* infection are strong independent predictors of poor visual outcomes and increased risk of globe loss in endogenous endophthalmitis.

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Re: Marmor et al.: Recommendations on screening for hydroxychloroquine retinopathy (2026 Revision) (Ophthalmology. 2016;123:1386-1394).

Garg … Costedoat-Chalumeau
OphthalmologyMar 6, 2026

Abstract not available — see full article for details.

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REPLY.

Marmor …
OphthalmologyMar 6, 2026

Abstract not available — see full article for details.

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Long axial length is a risk factor for infectious endophthalmitis in micro-incisional vitrectomy and membrane peeling surgery.

Yang … Byon
RetinaMar 3, 2026

Long axial length, high myopia, and myopic tractional maculopathy significantly increase the risk of infectious endophthalmitis following micro-incisional vitrectomy and membrane peeling, potentially linked to lower early postoperative intraocular pressure.

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Spectrum of Colopathy and Severe Polyposis Associated with Pentosan Polysulfate Sodium Maculopathy: A Retrospective Case Series.

Feo … Sarraf
Am J OphthalmolMar 3, 2026

Patients with pentosan polysulfate sodium (PPS) maculopathy are at high risk for concomitant and often asymptomatic colonic disease, including severe adenomatous polyposis requiring intervention, and inflammatory bowel disease.

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