RetinaDigest

Sleep deprivation (<6 hours on weekdays) was associated with a 1.25-fold increased risk of epiretinal membrane in a machine learning analysis of 15,240 Korean participants. The association was particularly strong among non-high-risk alcohol consumers and individuals with diabetes mellitus.

Abstract not available — see full article for details.

ChatGPT-5 showed high apparent accuracy in predicting full-thickness macular hole surgery outcomes but demonstrated significant optimism bias, overestimating closure rates and visual improvement compared to retinal specialists.

Abstract not available — see full article for details.

Bacillary layer detachment (BALAD) occurs in 18.9% of fovea-off rhegmatogenous retinal detachments, particularly in younger patients with greater subretinal fluid height, but does not negatively impact anatomical reattachment rates or surgical success.

This large retrospective cohort study found that tirzepatide use in diabetic patients was associated with significantly reduced risk of diabetic retinopathy progression and complications requiring intervention compared to lifestyle modification alone.

Abstract not available — see full article for details.

Meta-analysis of 353 eyes shows intravitreal and subretinal tissue plasminogen activator injections achieve comparable visual and anatomical outcomes for submacular hemorrhage treatment, with similar safety profiles.

In a 2-year prospective study of 276 eyes with early/intermediate AMD, incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) and acquired vitelliform lesions (AVLs) were the strongest independent predictors of progression to late AMD, with odds ratios of 29.60 and 15.90 respectively.

Abstract not available — see full article for details.

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Abstract not available — see full article for details.

Paracentral acute middle maculopathy (PAMM) demonstrated 100% specificity and positive predictive value for temporal artery biopsy positivity in suspected giant cell arteritis (GCA), making it a highly reliable non-invasive diagnostic marker.

Hyperreflective choroidal foci (HCF) in BRVO-associated macular edema decrease in the inner choroidal layers following treatment, with higher residual HCF counts predicting earlier recurrence and increased treatment burden.

Deep learning analysis of retinal images from routine ROP screening can predict bronchopulmonary dysplasia and pulmonary hypertension in premature infants, with multimodal models achieving AUCs of 0.82 and 0.91 respectively.

The blend function in ultra-widefield imaging provides superior stage-wise characterization of choroiditis compared to fundus autofluorescence, with the green channel offering better delineation of active inflammatory lesions and disease borders.

This retrospective study of 158 eyes with pediatric pars planitis found that mild cases can be safely observed without treatment, achieving similar visual outcomes to treated cases while avoiding medication-related complications.

Immunomodulatory therapy in sarcoidosis-associated choroidal neovascularization led to reduced need for intravitreal injections and trends toward improved visual acuity and anatomical outcomes.

In this retrospective cohort study of 175 uveitis patients, 13.7% developed CNS inflammatory lesions and specific uveitis characteristics including snowballs, intermediate/posterior location, and recurrence were associated with increased risk of symptomatic CNS disease.

Adalimumab treatment in Behçet's uveitis patients shifts NK cells toward an exhausted-like phenotype while rebalancing activating/inhibitory receptors, suggesting NK-receptor balance as a potential pharmacodynamic biomarker for treatment response.

Abstract not available — see full article for details.

A case report documents the first reported instance of endophthalmitis following intravitreal anti-VEGF injection linked to bacterial colonization of silicone punctal plugs, with Streptococcus oralis cultured from both the intraocular specimens and the explanted plugs.