RetinaDigest

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This meta-analysis of 637 eyes found pneumatic vitreolysis (PVL) achieves a 76% overall VMT release rate, making it a cost-effective first-line option for VMT without FTMH, though macular hole closure rates remain modest at 40%.

Among Hispanic/Latino adults with diabetes, over one-third had diabetic retinopathy with significant variation across subgroups, and hypertension was independently associated with both any DR and vision-threatening DR.

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Macrophage-stimulating protein (MSP) and its receptor RON are significantly elevated in the vitreous of patients with proliferative diabetic retinopathy (PDR), correlate with VEGF levels and active neovascularization, and represent potential novel angiogenic biomarkers in PDR.

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Approximately one-quarter of nAMD eyes in routine US practice did not receive anti-VEGF treatment within 29 days of diagnosis, and delayed treatment initiation was associated with significantly worse visual outcomes compared to prompt treatment (+5 vs. -3 letters at 1 year).

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This case report describes multimodal imaging findings in a 40-year-old woman with recurrent Susac syndrome, demonstrating how combined retinal and neuroimaging features—specifically branch retinal artery occlusion and central corpus callosal lesions—can distinguish Susac syndrome from multiple sclerosis and other neurological disorders.

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Using en face OCT and adaptive optics OCT, this study characterized outer retinal tubulation (ORT) in Bietti crystalline dystrophy (BCD) as complex three-dimensional planar structures spatially integrated with residual outer retina, supporting ORT as a manifestation of structural reorganization during progressive degeneration rather than an isolated finding.

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In a multicenter case series of 29 patients with refractory non-infectious uveitis, JAK inhibitors (primarily upadacitinib and tofacitinib) achieved remission in 22 patients with no serious adverse events, suggesting a safe and effective option after failure of conventional immunosuppressants and biologics.

A multicenter study of 329 treatment-naïve CSC eyes demonstrated that an interpretable Random Forest model applied to AI-derived baseline OCT biomarkers predicted disease chronicity with an AUC of 0.852, with parafoveal ONL thickness emerging as the strongest individual predictor.

In eyes with multifocal choroiditis (MFC) and punctate inner choroiditis (PIC), baseline RPE/Bruch's membrane complex disruption on OCT predicts incident CNV, while high myopia and progressive subfoveal choroidal thinning predict incident focal choroidal excavation (FCE).

In a large EMR-based study of over 150 million records, Behçet's disease patients with uveitis demonstrated more than twice the risk of skin, vascular, musculoskeletal, and CNS manifestations compared to those without ocular involvement, with a markedly shorter time to systemic disease onset (413 vs. 1729 days).

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A systematic review and meta-analysis of 16 studies found that deep learning models achieve excellent diagnostic accuracy for ocular toxoplasmosis on fundus photography (pooled sensitivity 96.5%, specificity 95.5%), but clinical translation is significantly limited by over-reliance on a single Paraguayan dataset and lack of multicentric external validation.

In this retrospective cohort of 29 patients developing uveitis after immune checkpoint inhibitor (ICI) therapy, prompt recognition and appropriate management resulted in generally stable long-term visual acuity, with median logMAR improving from 0.36 at baseline to 0.18 at final follow-up despite clinically significant inflammation.

In pediatric non-anterior uveitis, the HLA-DRB1*15:01 allele is strongly associated with intermediate uveitis, characterized by absent anterior chamber cells, prominent vitreous floaters, and peripheral fern-like capillary leakage on fluorescein angiography.

In a propensity score-matched analysis of 3,204 non-infectious uveitis patients, mixed autoimmune-autoinflammatory etiologies (JIA, Behçet's disease, psoriasis) and retinal vasculitis were the strongest predictors of adalimumab initiation, while bilateral and posterior uveitis were associated with earlier escalation to biologic therapy.

Intravitreal clindamycin significantly improved visual acuity (mean 0.54 logMAR improvement) in vision-threatening toxoplasmic retinochoroiditis, with adjunctive corticosteroids—either oral or intravitreal dexamethasone—showing no statistically significant additional benefit on visual outcomes or complication rates.

This case series demonstrates that choroidal tuberculosis in miliary disease can present without any intraocular inflammation, and ICGA is superior to FFA and autofluorescence in detecting the full burden of choroidal lesions in immunocompromised patients.

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In a retrospective cohort of 390 patients with non-infectious uveitis, high BMI and smoking history were independently associated with a significantly increased likelihood of developing uveitic macular edema, identifying two potentially modifiable risk factors for this vision-threatening complication.

In this 40-year retrospective series of 569 patients with ocular metastases, median overall survival remained dismal at 8.2 months and did not improve significantly over time, despite advances in systemic therapies.

This pilot study demonstrated that radiomic analysis of anterior segment OCT images can distinguish active from inactive vitreoretinal lymphoma with an AUC of 0.74, suggesting potential for non-invasive disease monitoring, though the approach requires further validation before clinical application.

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